Cornell Genomics Initiative

A PATHWAY FROM DNA TO DRUGS

A better understanding of the gene-protein link could help to cure hereditary diseases. A future scenario might go like this:

  • By comparing DNA samples from several generations of an extended family, geneticists find out where on the chromosomes the gene for a particular trait is located.

  • Biochemists sequence the DNA on that part of the chromosome and from that determine the sequence of amino acids in its protein.

  • A computer simulation shows what the folded shape of the protein will be.

  • From images of the protein, experienced biochemists may be able to deduce its function; or, a search of a database of shapes might provide clues.

  • A drug or genetic therapy can be devised to counter the damage done by a defective gene.

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